Nate Mendel met Kate Jackson, co-founder of independent public relations firm Grandstand Media, in 2009 while she was director of marketing and publicity at Sub Pop Records and Mendel was touring as part of a reunion of the original lineup of Sub Pop recording artists Sunny Day Real Estate. After dating for several years, Mendel and Jackson married on October 11, 2014, in an intimate and private wedding ceremony in Los Angeles attended by close friends and family including Nate’s Foo Fighters bandmates. On July 19, 2018, Mendel took a one-show leave of absence from the Foo Fighters’ Concrete & Gold tour, with Jane’s Addiction bassist Chris Chaney filling in for him for one night at the PPG Paints Arena in Pittsburgh, as he chose to be with Jackson as she gave birth to the couple’s twin girls. Mendel has one other child, Noah from a previous marriage.